Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury
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چکیده
منابع مشابه
Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury
Background Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans. There are many important differences between spinal cord injury in experimental animals and in human clinical cases, making it difficult to introduce new therapi...
متن کاملPharmacodynamics and pharmacokinetics of the oral antispastic agent tizanidine in patients with spinal cord injury.
The efficiency and duration of action of a single oral dose (8 mg) of tizanidine in patients with spinal cord injuries were determined by studying its antispastic, cardiovascular and sedative effects along with its pharmacokinetic profile in five tetraplegic and five paraplegic patients. After the administration of tizanidine, there was a reduction in spasticity in both groups within half an ho...
متن کاملELECTROEJA CULATION FOR FERTILITY IN MEN WITH SPINAL CORD INJURY
From October 1990, to June 1992, more than 800 electroejaculations and 108 intrauterine inseminations (IUI) were performed in 250 paraplegic males and their wives. Seven successful pregnancies are the results of this 20-month effort. This is the first report of electroejaculation and successful pregnancy with its use in paraplegics in Iran and the Middle East.
متن کاملFrequency of Phantom Pain among patients with Spinal Cord Injury
Summary: Background: Patients with spinal cord injury (SCI) usually have permanent and often devastating neurologic deficits and disability and pain (1). According to the National Institutes of Health, "among neurological disorders, the cost to society of automotive SCI is exceeded only by the cost of mental retardation"(2). Neurogenic pain constitutes one of the enigmatic clinical sy...
متن کاملChanges of the Electrophysiological Study in Dogs with Acute Spinal Cord Injury.
OBJECTIVE This study describes a method for inducing spinal cord injuries in dogs by using balloon catheters via laminectomy and the subsequent changes in the electrophysiological response. METHODS Female Beagle (Orient Bio, Seongnam, Korea) dogs weighing 10 kg at the time of injury were used. Under inhalation anesthesia, a posterior midline approach laminectomy was performed. A silicone ball...
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ژورنال
عنوان ژورنال: PeerJ
سال: 2018
ISSN: 2167-8359
DOI: 10.7717/peerj.4387